7-Amino-3-cephem-4-carboxylic acid
Basic Information:
Zita rechirungu:
7-ANCA;7-AMOCA;(6R,7R)-7-AMino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7- NACA,7-ANCA;7-ANCAChemicalbookimpurity;CeftizoximeKusachena9;CeftizoximeKusachena16;Ceftizoximeintermediate(7-anca);7-amino-3-cephem-4-carboxylicacid
Nhamba yeCAS: 36923-17-8
Molecular formula: C7H8N2O3S
Molecular uremu: 200.21
EINECS nhamba: 609-312-7
Structural formula:
Zvikamu zvinoenderana: Organic intermediates; Pharmaceutical intermediates; Pharmaceutical raw materials.
Kunyungudika: 215-218°C
Poindi yekuvira: 536.9±50.0 °C(Zvakafanotaurwa)
Density: 1.69± 0.1g /cm3(Zvakafanotaurwa)
Refractive index: 1.735 (kufungidzira)
Painopenya: 278.508°C
Solubility: Soluble mu acidic aqueous solution (zvishoma, zvinopisa), DMSO (zvishoma). Zvivakwa: Muchena kana chena crystalline poda.
Kutsikirira kwehutsi: 0mmHg pa25°C
| tsanangudzo | unit | standard |
| Chitarisiko | Muchena kana chena crystalline poda | |
| Main content | % | ≥98.5% |
| Unyoro | % | ≤1 |
| Mono hybrid | % | ≤0.5 |
| Total clutter | % | ≤1 |
Cephalosporin, inoshandiswa sepakati pecefbutan uye cefazoxime.
Yakaiswa sulfuric acid (104.3mL, 1.92mol) yakawedzerwa mumabhodhoro matatu, ipapo isophthalic acid (40g, 0.24mol) yakawedzerwa, yakamutswa uye inopisa kusvika 60 ℃, yakachengetwa kwe0.5h, uye 60% nitric acid (37.8g, 0.36) mol) yakawedzerwa kudzora dhigirii rekumhanyisa kudonha. Wedzera mumaawa maviri. Mushure mekuwedzera, kupisa kwekuchengetedza maitiro pa60 ℃ kwemaawa maviri. Kutonhora kusvika pasi pe50 ° C, wobva wawedzera 100mL yemvura. Nyaya yacho yakanyoroveswa kusvika kune tembiricha yekamuri, yakadururirwa musefa, yakapombwa kuti ibvise marara asidhi, keke resefa yakashambidzwa nemvura, yakanyungudutswa kuti iite recrystallize, uye chigadzirwa chichena chaive 34.6 gramu, goho raive 68,4%.
20Kg kana 25Kg/bucket, cardboard bucket, rakaiswa jira jena nebhegi dema repolyethylene. 2 ℃-8 ℃ yakaoma, inotonhorera nzvimbo, kure nechiedza chekuchengetedza, inoshanda kwemakore maviri.
