2-methyl-5-nitroimidazole
Basic Information:
Zita remakemikari: 2-methyl-5-nitroimidazole;
Zita reChirungu: 2-Methyl-5-nitroimidazole;
Nhamba yeCAS: 88054-22-2
Molecular formula: C4H5N3O2
Huremu hwemorekuru: 127.1
EINECS nhamba: 618-108-7
Structural formula:
Zvikamu zvinoenderana: mbishi zvinhu; Pharmaceutical intermediates; Pharmaceutical raw materials.
Density :1.4± 0.1g/cm3
Kuvira poindi :399.5±15.0°C pa760 mmHg
Kunyungudika: 252-254ºC
Flash point :195.4±20.4°C
Chaiyo misa :127.038177
PSA:74.50000 LogP:-0.10
Kuonekwa: White crystal
Mhepo yehutsi :0.0±0.9 mmHg pa25°C
Refractive index :1.592
Mamiriro ekuchengetedza: akavharwa munzvimbo inotonhorera uye yakaoma ye0-6 ºC
Kugadzikana: haizoparari kana ichishandiswa uye ichichengetwa maererano nemitemo.
| tsanangudzo | unit | standard |
| Chitarisiko | Kufanana nehupfu chena kana yero | |
| Content | % | ≥99% |
| Unyoro | % | ≤0.3 |
| Sulfate | % | ≤0.3 |
Inonyanya kushandiswa mukugadzirwa kwemetronidazole, dimetazole uye mamwe madhiragi ari pakati.
Inowanikwa ne nitration ye2-methylimidazole. Isa sulfuric acid, 2-methylimidazole uye sodium sulfate muhari inopindura, kurunga uye kupisa, wedzera nitric acid pa150-160 ℃, wedzera kumusoro, tevera maitiro ecasket kweawa imwe. Bvisa tembiricha kusvika 140 ℃ pazasi, mushure mekuwedzera mvura nemvura yeammonia kugadzirisa pH kusvika 3.5-4, crystallization. Simbisa, geza kusvika kune kwazvakarerekera, kuoma, 2-methyl-5-nitroimidazole.
25k kraft bepa bhegi kana bhegi rakarukwa (58 × 110) rakaiswa bhegi repurasitiki, 250kg kunze kwemudziyo bhegi (100 × 80); Maererano nezvinodiwa nevatengi;
Chisimbiso chekuchengetedza, chakachengetwa munzvimbo inotonhorera, yakasviba, yakaoma, yekuchengetedza uye yekufambisa inofanira kuva yakareruka, kudzivirira kukanganisa uye unyoro, inorambidzwa zvakasimba nemishonga yakasanganiswa.
Nzira yekugadzira: Inowanikwa nenitrate ye2-methylimidazole. Isa sulfuric acid, 2-methylimidazole uye sodium sulfate muhari inopindura, kurunga uye kupisa, wedzera nitric acid pa150-160 ℃, wedzera kumusoro, tevera maitiro ecasket kweawa imwe. Bvisa tembiricha kusvika 140 ℃ pazasi, mushure mekuwedzera mvura nemvura yeammonia kugadzirisa pH kusvika 3.5-4, crystallization. Simbisa, geza kusvika kune kwazvakarerekera, kuoma, 2-methyl-5-nitroimidazole.
