Nucleosides, zvivharo zvekuvaka zve nucleic acids (DNA neRNA), inoita basa rakakosha mukuchengetedza ruzivo rwemajini uye kutamisa. Kunyange zvazvo nucleosides yakajairika-adenine, guanine, cytosine, thymine, uye uracil-inozivikanwa zvikuru, ndiyo nucleosides yakagadziridzwa iyo inowanzowedzera mutsara wekuoma uye kushanda kune biological systems.
Chii chinonzi Modified Nucleosides?
Yakagadziridzwa nucleonides ndeye nucleotides iyo ine pasi pemakemikari yekugadziridzwa kune yavo base, shuga, kana boka rephata. Izvi zvinoshandisika zvinogona kuchinja zvimiro zvemuviri uye zvemakemikari zvechemaketi
Mhando dzekunatsiridza uye nemabasa awo
Base Modifications: Izvi zvinosanganisira shanduko kune nitrogenous base ye nucleotide. Mienzaniso inosanganisira methylation, acetylation, uye glycosylation. Base shanduko inogona kukanganisa:
Kugadzikana: zvigadziko zvekumisikidzwa zvinogona kuwedzera kugadzikana kwema acceic acids, achivadzivirira kubva mukusvibiswa.
Kuzivikanwa: Mabhesi akagadziridzwa anogona kushanda senzvimbo dzinozivikanwa dzemapuroteni, achifurira maitiro akaita seRNA splicing uye protein synthesis.
Basa.
Shuwa shanduko: Kugadziridzwa kuRubatshi kana Deoxyribase shuga inogona kukanganisa kuenderana uye kugadzikana kweiyo nucleic acid. Kugadziriswa shuga kwakajairika kunosanganisira methylation uye pseudouridylation.
Phosphate Kugadziriswa: Shanduko kumusana wephosphate inogona kukanganisa kugadzikana uye kushanduka kweiyo nucleic acid. Methylation yemapoka ephosphate inowanzoitika.
Mabasa eModified Nucleosides muBiological Systems
Rna kugadzikana: Yakagadziridzwa nucleessides inobatsira mukugadzikana kweRNA mamorekuru, achivadzivirira kubva mukusvibiswa.
Protein Synthesis: Yakagadziridzwa nucleosides mutRNA inoita basa rakakosha muprotein synthesis nekupesvedzera kupindirana kwekodon-anticodon.
Gene Regulation: Kugadziridzwa kuDNA neRNA kunogona kudzora mataurirwo ejini nekukanganisa kunyora, kupatsanura, uye kududzira.
Viral Replication: Mavhairasi mazhinji anoshandura nucleic acids kuti adzivise immune system.
Chirwere: Kuchinja kwemaitiro akagadziridzwa nucleoside kwakabatanidzwa kune zvirwere zvakasiyana-siyana, kusanganisira kenza.
Zvishandiso zveModified Nucleosides
Therapeutic Agents: Nucleosides yakagadziridzwa inoshandiswa mukugadzirwa kwemishonga inorwisa mavhairasi uye anticancer.
Biomarkers: Yakagadziridzwa nucleosides inogona kushanda sema biomarker ezvirwere, ichipa manzwisisiro mumaitiro echirwere.
Synthetic Biology: Akagadziridzwa nucleosides anoshandiswa kugadzira synthetic nucleic acids ine novel properties.
Nanotechnology: Yakagadziridzwa nucleosides inogona kushandiswa kugadzira nanostructures kune akasiyana maapplication.
Mhedziso
Yakagadziridzwa nucledides zvakakosha zvikamu zveBiologys masisitimu, kutamba masangano akasiyana siyana muhurukuro yeGene, mutemo, uye cellular maitiro. Zvivakwa zvavo zvakasarudzika zvakavaita zvishandiso zvakakosha muBiotechnology, mushonga, uye nanotechnology. Sezvo kunzwisisa kwedu kwemamorekuru aya kuri kuramba kuchikura, tinogona kutarisira kuona mamwe maapplication matsva achibuda.
Nguva yekutumira: Jul-31-2024